Sentence examples for essential player of from inspiring English sources

Similarly, we detected nucleocytoplasmic shuttling of RAN, an essential player of the RAN-dependent nucleocytopasmic transport [ 30, 31].

The PQC consists of molecular chaperones and degradation systems and is an essential player of the proteotoxic stress response.

The human 18q21.1-q21.2 region, constantly disrupted in human CRC [ 15, 16], encodes the bona fide CRC gene SMAD4, which is an essential player of the transforming growth factor-β (TGF-β) signaling pathway.

By taking advantage of a medaka model that recapitulates the MLS phenotype we demonstrate that downregulation of hccs, an essential player of the mitochondrial respiratory chain (MRC), causes increased cell death via an apoptosome-independent caspase-9 activation in brain and eyes.

Therefore, it was suggested that B-cells are essential players of the disturbed immune system, which fuelled interest in B-cells as drug target.

Causative genes of both BSCL3 and BSCL4 are somewhat related in that both CAV1, a structural protein, and PTRF/cavin-1, a transcription factor, are essential players of caveolae formation [ 43, 44].

Our results also imply a close interaction of a microtubule-associated translation control unit with PP2A and its negative regulators α4 and MID1, all essential players of mTOR signalling.

Oxidative stress then resulted in the loss of mitochondrial membrane potential and the release of several essential players of the mitochondrial apoptosis pathway, such as cytochrome c and apoptosis-inducing factor into the cytosol as well as the activation of caspases and apoptotic protease-activating factor-1 (Kannan and Jain, 2000; Henry-Mowatt et al, 2004).

We have found that the native Nde1 protein in the developing mouse tissue is very insoluble and exists at a relatively low level, but genetic studies have shown that Nde1/NDE1 is an essential player for various pivotal aspects of the neural progenitor biology.

Like most biographies of objects, this one presents its subjects as essential players on the global stage.

A common thread in these challenges is the lack of ability for all the essential players to communicate about electricity supply, demand, and prices.