This knowledge could be useful for designing inhibitors of this essential pathway in bacteria or for engineering LspA.
Such lethality arises due to several reasons including interchangeable gene products with respect to an essential function (isozymes/isoforms), their existence in the same essential pathway or sharing of complementary essential function(s) (Suthers et al. 2009).
On the other hand, intact NF-κB signaling is not only an essential pathway in many cancer entities, such as mucosa-associated gastric lymphoma, Hodgkin's disease, and diffuse large-B-cell lymphoma, but can compromise the response to anticancer therapies (Schmitt 2003).
When a child looks up to us -- and, in return, feels our genuine interest, warmth and pride -- we have strengthened an essential pathway of healthy emotional development, a pathway that leads toward commitment and ideals, and becomes a foundation for a child's sense of purpose in life.
Thus, we performed further perturbations to assess whether the IKK is an essential pathway in the network.
The synthetic lethal screen is generally employed to identify genes encoding proteins that function in a parallel pathway or with overlapping functions within an essential pathway.
AQP3 water channels have been pointed out as an essential pathway for volume-regulatory water transport in human epithelial cells [185].
On the other hand, in metazoans, the SAC is an essential pathway, the integrity of which is required to prevent chromosome mis-segregation and cell death [2].
The production of sugars from gluconeogenesis should be an essential pathway for aggregation in S. Typhimurium, particularly when strains are grown on amino-acid based media, such as tryptone or LB [42].
Thus, besides the functional characterization of a new mutant and a better understanding of ARL-1 GDP/GTP cycling, this work shows that Leishmania ARL-1 is a key component of an essential pathway worth future study.
An explanation for the purifying selection across these genes is that functions such as translation are crucial for an organism's basic function and therefore any changes to the protein sequence may cause disruption towards this essential pathway.
