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More detailed analysis is, unfortunately, complicated by essential overlapping of broadened bands that is typical for solid solutions containing tetrahedral and octahedral complexes with central atoms whose masses are close to each other.
Loss of replication due to a deletion of the whole UL49 locus may be caused by deletion of essential overlapping ORFs because the UL49 ORF overlaps with UL50 ORF and UL48.5 ORF nearby.
These three proteins carry out essential overlapping functions in the development, as demonstrated by phenotypes of double or triple knock-out mice.
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The observed grey matter reductions did not show essential overlap with the abnormalities detected by fluorodeoxyglucose-PET or functional MRI.
Ventura A, Garfinkel AG*, Winslow MM*, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JA, Jaenisch R, Sharp PA, and Jacks T. Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17~92 miR-17~92 miRNA Clusters.
These findings support a model in which GNA-2 is required for CHS-1-dependent synthesis of eggshell chitin, which binds CEJ-1 and B0280.5, proteins with essential but overlapping roles in meiotic chromosome segregation, polar-body extrusion, osmotic barrier function and polarization.
There was nearly complete overlap between putative essential genes determined by Tn-seq with the P. gingivalis core genome, 434 of 463 (93.7%) putatively essential genes overlapped (Additional file 1: Table S1) [ 38].
An overlapping essential gene in the Potyviridae.
miRNA data are not reported here due to several confounding caveats, such as overlapping essential genes and the less straight forward targeting of non-coding RNAs using CRISPR/Cas9.
The HSP family members play overlapping, essential roles in tumor growth both by promoting autonomous cell proliferation and by inhibiting death pathways.
In both cases these modes are assumed to be essential and maximally overlapping.
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