In a quest to identify the source of microtumors in Ubc9 mutants, we discovered that even though Ubc9 protein is ubiquitously expressed, it plays a specific and essential, niche-independent function in maintaining proliferative quiescence within progenitors of the medullary and transition zones.
Previous studies have shown that Nestin MSCs constituted an essential HSC niche component and can be propagated as nonadherent 'mesenspheres' that can self-renew and expand in serial transplants, whereas Sox2 stem cells are crucial for normal tissue regeneration and survival.
These studies provide a framework for studying crypt morphogenesis and identify essential regulators of niche formation.
Tumor microenvironment is an essential and vital niche in support for the developmental process of tumors.
Thus, Paneth cells, daughters of Lgr5 stem cells, provide essential stem cell niche signals.
These findings together with the observation that a naphthalene-resistant subpopulation of club cells is associated with NEBs [ 16, 62] led to the hypothesis that pulmonary NEBs form a stem cell niche essential for club cell regeneration during lung injury.
We will focus on the relatedness category assignment (RCA) method in this paper because knowledge about relatedness categories provides essential information for niche inheritance, cultural inheritance, and epigenetic inheritance studies.
Indeed, regression of the neuropil represents the progressive disruption of the striatal microenvironment, including the vascular niche, essential for the viability and functioning of all the components of striatal tissue, which even more contributes to worsening of the entire process.
Mr. Meecham, who lives in Hastings, said "developing a niche" was essential in a small market like Westchester.
Figleaves.com, which opened in March, is all about what the apparel industry calls "essential wear" -- a niche Ms. Strasser said she and her colleagues focused on after first considering a broader plan to get into the online apparel business.
