Sentence examples for essential mutation from inspiring English sources

While the 4.5S RNA gene is not essential, mutation impairs bacterial growth, lowers virulence factor secretion, and reduces virulence in a mouse infection model.

We categorize a given mutation profile m as: essential mutation, when m is absent in all drug-susceptible strains, conflict mutation, when m is present in at least one drug-susceptible strain.

According to Taubenberger, this suggests a new strategy for surveillance, one that would include identifying and isolating a local variant of the virus on the verge of acquiring a complete complement of the essential mutations, after which point it would become impossible to contain.

From this systematic structure-function analysis we demonstrate that all essential mutations studied map to one hemisphere of the protein and provide strong evidence in support of the proposed ArfGEF contact site on Arf1p but minimal evidence in support of the proposed ArfGAP-binding site.

Further, we distinguish neutral mutations as a subclass of essential mutations, these are essential mutations that are not present in any of drug-resistant strains.

Summarizing information for the top scored point mutation profiles, only for essential mutations.

Interestingly, two of the mutations in the top 10 essential mutations according to weighted support (I72 F in SAR0420 and E208 QKD in SAR0436) are present in cell membrane proteins.

Synthetic lethality describes a cellular condition in which two (or more) non-allelic and non-essential mutations, which are not lethal on their own, become deadly when present within the same cell.

Clearly, genome-scale predictive methods that filter out benign or small changes in mRNA splicing due to sequence variation will be essential for mutation discovery in exomes, complete genomes and high-density targeted deep sequencing projects.

In particular, the second glycine, G402, was shown to be essential, since mutation of this residue resulted in elimination of autophosphorylation.

Each allele with either a nonsense or essential splice mutation is analysed for morphological differences during the first 5 days of development.