Sentence examples for essential molecular features from inspiring English sources
The QSAR model thus developed helps in quantification of the extent of contribution of the various molecular fragments towards the activity of the molecules, while the 3D pharmacophore model provides a brief idea of the essential molecular features that help the molecules to interact with the neighbouring free radicals.
Based upon analysis of multiple influenza sequence alignments, pan-influenza virus RT-PCR primer sets were developed that were capable of amplifying all three influenza virus species (A, B, and C) and subtypes (HxNy) from different animal hosts (e.g., human, avian, and swine) and distinguishing essential molecular features using base composition signatures.
Nevertheless, to the best of our knowledge, the variable influence of PrPc expression levels according to the form of prion disease defined by its essential molecular features, has never been described and is here reported between different animals in a same transgenic mouse line.
The agreement between simulations and experiments suggests that the CG model correctly reproduces the essential molecular features of topogenesis; in the following, we analyze the ensembles of CG trajectories that give rise to these computed IMP topologies.
The QSAR, pharmacophore mapping and docking studies provide an understanding of important structural requirements or essential molecular properties, or features of molecules, and important binding interactions, and provide an important guidance for the chemist to synthesis of new molecules with improved PfTMPK inhibitory activity profile.
We have used this compound series containing 18 compounds for building the 3D-QSAR model and to identify the molecular features essential for effective interaction between the inhibitors and the active cleft of the mPTPB enzyme.
In this study, a congeneric dataset comprising of 28 thiosemicarbazone derivatives was first chosen to build a 3D QSAR model that evaluates the activity of the ligands against cathepsin L. And we also find out the molecular features essential for their activity using the pharmacophore model.
It is believed that the underlying molecular features of the tumors play an essential role in determining the aggressiveness of the tumors.
Platelets are able to recognize molecular features of microbes and secrete many immunomodulatory mediators essential for alerting and recruiting cells of the immune system [4 7].
4 Quantitative models relating the molecular features of tumors to pharmacologic response patterns are thus essential for achieving the vision of precision medicine.
A greater understanding of the molecular features that distinguish polypoid and nonpolypoid precursors of colorectal cancer is essential for their effective clinical management and for cancer prevention.
