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"essential modification" is a correct and usable phrase in written English.
You can use it when you are discussing the importance of making adjustments to a system or plan. For example, "In order to make the plan successful, essential modifications must be made to ensure effectiveness."
Exact(19)
N-linked glycosylation is an essential modification of secretory and membrane proteins in all eukaryotic cells.
It was found that plasma treatment could induce an essential modification of the surface of electrospun NSF scaffolds.
Almost all benzimidazoles with different heterocyclic substituents led to essential modification in their physico-chemical, metabolic and pharmacokinetic properties [9].
In the cases that the lower amount of sulfur content in gas condensate will be required, some essential modification can be carried out as follows: A larger reactor.
Sulfation is an essential modification of carbohydrates and proteins.
Sulfation is an essential modification of many carbohydrates and proteins, and is necessary for normal growth and development.
Similar(41)
The paper presents three essential modifications of the current analysis of the dynamic along-wind response of simple structures.
A compact wearable sensor applied in healthcare and well-being application is demonstrated as a real-life application with emphasis on the essential modifications and original contributions required to achieve efficient and reliable networks.
351 (2010) 21 27], experiments with hazardous and highly toxic gas such as H2S especially at high concentration (i.e., 20,000 ppm) and pressures necessitated essential modifications of the previously described experimental setup to ensure safe operations.
Since, then, these are essential modifications of unity qua unity and of being qua being, not qua numbers or lines or fire, it is clear that it belongs to this science to investigate both the essence of these concepts and their properties.
The conventional hybrid frequency-time domain approach, which is available in the state-of-the-art computer codes, is implemented to model the hydrodynamic loads on each structural component with essential modifications with respect to the corresponding hydrodynamic coefficients, e.g. added mass and potential damping coefficients and wave excitation forces.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com