Sentence examples for essential model organisms from inspiring English sources

The fruit fly D. melanogaster and the roundworm C. elegans have been essential model organisms for studying development and disease, in part because it is relatively easy to create mutants that allow the functions of individual genes to be investigated.

The nematode Caenorhabditis elegans has become an essential model organism in neuroscience research because of its stereotyped anatomy, relevance to human biology, and capacity for genetic manipulation.

Nevertheless, PRKDC is not essential in model organisms, demonstrated in both genetically engineered and spontaneous animal models [ 55, 57– 60], which may afford a potential safe therapeutic window for future drug development.

Essential genes from model organisms were mapped to orthologous groups in vertebrates, arthropods, and fungi.

Therefore, a resource such as described here for identifying and studying essential genes in model organisms has direct benefit.

Researchers have found that hubs within a protein interaction network are encoded by essential genes in model organisms [ 39].

In support of this notion are recent findings of Waterhouse et al. [ 33] who demonstrated that the essential genes from model organisms are significantly enriched in orthologs across the vertebrate, arthropod and fungal lineages.

Analysis of essential genes in model organisms has lagged behind that of nonessential genes because of the inherent difficulty in conducting genetic experiments on strains lacking a protein required for cell growth.

With essential genes from representative model organisms, we aimed to explore the expectation of broad phyletic distributions of essential genes across dozens of eukaryotic species from three distinct lineages.

To investigate essential gene requirements in model organisms, multiple approaches have been used to reduce gene function and infer gene requirements based on the resulting mutant phenotypes.

Thousands of genes have been identified as essential genes in multiple model organisms, such as Saccharomyces cerevisiae, Caenorhabditis elegans, and Mus musculus [ 5- 7].