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Our findings demonstrate that LGP2, though not essential, is required for generation of optimal cytokine responses to intracellular dsDNA, infection with the bacterium Listeria monocytogenes (LM) and the pox virus, modified vaccinia virus Ankara (MVA).
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Our results suggest that these previously uncharacterized genes, although not essential, are required for full nitrogenase activity.
Thus, well-considered approaches to predict the most promising targets and to identify those most likely to be essential are required to increase the likelihood that lead compounds proceed to commercial development [ 2].
While diligent enforcement is essential, this is required for all hazardous toys and should not excuse inaction.
This essential biomolecule is required by animals and humans, but can only be synthesized by bacteria and archaea [32].
Iron, an essential nutrient, is required for many diverse biological processes.
To initiate such combination therapy, essential knowledge is required about the general immune modulatory effect of 5-Azacytidine.
Iodine is an essential nutrient that is required for the production of thyroid hormone.
SV2 is an essential protein that is required for normal neurotransmission [9], [10].
Therefore, we propose that σE is indeed essential because it is required to transcribe genes in its regulon.
CDC20 is an essential gene that is required to activate the Anaphase Promoting Complex (APC) in metaphase, and therefore controls anaphase and ultimate mitotic exit.
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