Sentence examples for essential invasion from inspiring English sources

PfRh5 is the only essential invasion ligand within the PfRh family and is an important vaccine candidate.

However, three CDS for conserved hypothetical proteins were found replacing sipC, an essential invasion gene and invIJ, encoding putative effectors [ 35, 36].

Two recent proof-of-concept studies identified small molecule invasion inhibitory compounds targeting interactions between essential invasion ligands RON4-AMA1 (inhibitorangenge 30 6 μM) and MSP1-19 (replinhibitionhibition 21.7 μM) [ 12, 14], and reported invasion inhibitory IC50 values in a very similar range to azithromycin and analogues.

Since palmitoylation is apparently essential for invasion, and because several invasion motor complex components are palmitoyl proteins, we next treated schizonts (approximately 42 44 hr after invasion) with 50 μM 2-BMP for 2 4 hr and examined its effect on specific complex members (Baum et al., 2006; Jones et al., 2006).

These results lead us to hypothesize that [i] a combination of adhesion and cytotoxicity is essential for invasion, and [ii] the invasiveness is a multi-factorial process in which ShlA plays a major, but also confounding role.

Notably, Rho/Rock pathway is essential to invasion in all conditions suggesting that Rho is important mediator of tumor cell invasion.

The destabilizing effect of 2-BMP on PfGAP45 and PfMTIP provides an explanation for its invasion-inhibitory effect; however, it is likely that 2-BMP also affects other palmitoyl proteins essential for invasion.

Cell migration of tumor cells is essential for invasion of the extracellular matrix and for cell dissemination.

Apical membrane antigen 1 (AMA1) is essential for invasion of erythrocytes and hepatocytes by Plasmodium parasites and is a leading malarial vaccine candidate.

To explore this role, our lab conducted a functional proteomic screen for extracellular proteins that are essential for invasion in fibrosarcoma cells.

The ability of mutant sporozoites to move by gliding motility is essential for invasion and was assessed by their ability to 'glide' on glass slides [40].