Sentence examples for essential interaction with from inspiring English sources

Transcription is initiated by the hijacking of nascent, capped host transcripts by the process of 'cap-snatching', for which the viral polymerase makes an essential interaction with the C-terminal domain (CTD) of cellular RNA polymerase II.

A unique and selective tool to inhibit AdoMetDC in trypanosomatids may be to prevent its essential interaction with prozyme.

Furthermore, the protein binding patterns between 11a and AChE/BACE 1 showed that it makes several essential interactions with the enzymes.

Finally, the screened compounds having structural features of both pharmacophore models and displaying essential interactions with both proteins were investigated for ADME properties.

Cyanovirin-N (CV-N) exerts a potent human immunodeficiency virus (HIV -inactivating activity against diverse strains of HIV -inactivating the viractivityce envelope glycoprotein gp120 againstcking its essential interactions with cellular receptors.

We have shown here that, compared to simply ranking the poses output by the docking program according to a single docking score, an initial filtering of the docked poses with a pharmacophore query to remove poses that do not form certain essential interactions with the target binding site greatly improves the quality of the results.

In addition to its major role in exocytotic transport (5), p115 functions in retrograde Golgi-to-ER trans-port, intra-Golgi transport and Golgi biogenesis [6] of the Golgi apparatus, due to essential interactions with the coat-protein complex I (COP I) subunit β-COP [7] and the conserved-oligomeric-Golgi complex (COG) subunit COG2 [8].

This could result from evolutionary selection against retrotransposon integration near tissue-specific genes because it might disrupt essential interactions with distal regulatory elements [ 40].

However, from the high-resolution structure of the IBC [ 4], an NT region truncated at residue 581 is likely to disrupt an α-helix (α9 in [ 4]), the NT of which forms essential interactions with IP3.

Given the high level of conservation of these individual binding sites, there appears to be strong evolutionary selection for a particular HD-preferred sequence, a process that may be driven by the requirement for maintaining essential interactions with other TFs in a given regulatory context.

Refrain from non-essential interaction with the opposite gender.