Sentence examples for essential initial step from inspiring English sources

This is an essential initial step towards engineering tissues of defined anatomical and histological structures.

Adherence of bacteria to host cells is generally considered to be an essential initial step in the colonization process [15].

An increase in knowledge is the essential initial step in incorporating PEH information into health professionals' education and practice.

Importantly, here, we have shown that extracellular Ca2+ and KCa3.1 activity are required for the TGFβ1-dependent phosphorylation and nuclear translocation of Smad2/3, an essential initial step in Smad2/3 activation.

Given limited resources available for HPSR in LMICs and the large number of issues to be researched, priority setting is an essential initial step to undertaking meaningful, policy-relevant research.

Albeit, the screening of patients subjected to nutritional risk is considered as an essential initial step in the structured process of nutrition care, in order to identify those who will likely benefit from proper nutritional management, is usually overlooked, and is still away from being routinely implemented in hospitalized patients.

Both cell culture and mouse models have provided evidence that essential initial steps in tumorigenesis involve the loss of senescence checkpoints and immortalization, which allow a cell to grow indefinitely and to go through further oncogenic steps, resulting in fully malignant behavior.

We identified FLNa as an interacting partner of CCR2B and demonstrate that FLNa is essential for the initial step of receptor endocytosis after ligand stimulation.

Randomised studies of the effect of dose intensity in ovarian carcinoma are essential, but an initial step must be to assess whether the proposed high dose treatment can be delivered.

Thus, it is conceivable that endogenous TGF-β is in the initial step essential for osteoclastogensis induced by a combination of receptor activator of NF-kB ligand (RANKL) and M-CSF [39].

Low levels of H3K9me persist at the centromeric repeat regions in RNAi-deficient cells (Sadaie et al. 2004) and play an essential role in the initial step of heterochromatin formation (Partridge et al. 2007).