Sentence examples for essential function in normal from inspiring English sources

Ikaros is required for the development of cDCs and pDCs in line with its essential function in normal development of early haematopoietic progenitors (Nichogiannopoulou et al, 1999).

The HR is frequently accompanied by programmed cell death (PCD), which plays a particularly important role in the defense against biotrophic pathogens but is also an essential function in normal plant development and differentiation [ 2].

The vasculature has essential functions in normal adult physiology and contributes to diseases by participating in inflammation and by supporting growth and spread of cancer1,2.

Several limitations arise from the complexity and multiple functions of the IGF/INS axis: (a) The IGF/INS axis is a molecular network that exerts essential functions in normal tissues (e.g. control of growth processes, tissue homeostasis, differentiation and metabolism).

These studies demonstrated cofilin-1 plays an essential role in normal functions of podocytes.

An increasing number of studies indicate that adult neurogenesis plays an essential role in normal memory function [11], [33].

Because EGFP was shown to impair actin-myosin interactions in muscle cells [3] and to induce dilated cardiomyopathy in EGFP mice [4], it is tempting to speculate that actin ubiquitination might play an essential role in normal muscle functioning and that its deregulation by EGFP causes the above mentioned phenotypes.

All Sse1 mutants isolated provide essential functions in the cell under normal growth conditions, further demonstrating that essential chaperone functions in vivo can to some degree at least be detached from those related to propagation of prions.

Nonetheless, it is also possible that fundamental pathways and networks are effectively larger as a result of relatively high-level component redundancy, a feature that would increase their robustness and versatility and ensure essential cellular functions in normal tissues under a variety of conditions.

Identifying and understanding these changes in dendrite morphology are essential for understanding brain function in normal and disease states.

Evidence from this work reveals a unique and essential function of SBEI in normal plant development, consistent with the evolutionary conservation of SBEI in all higher plants.