Sentence examples for essential for transformation from inspiring English sources

Interestingly, while in vivo methylation was essential for transformation, we did not obtain transformants when pMTL85141 was methylated in vitro with M.SssI or M.CviPI methyltransferases, although both enzymes protect pMTL85141 from digestion by CpaAI.

Presence of acetosyringone (AS) was found to be essential for transformation (Mohanty et al. 1999) whereas no transformation occurred in the absence of acetosyringone (Hoque et al. 2005).

For instance, the RecA protein is essential for transformation in Bacillus subtilis and Streptococcus pneumoniae, and expression of the RecA gene is induced during the development of competence for transformation in these organisms.

This suggests that the concerted action of both pathways is essential for transformation by this oncogene.

We also report that activation of both MAP kinase and PI3K signaling pathways are essential for transformation by 14-3-3γ 14-3-3γ 14-3-3γ

Developing models for the latter would be useful to identify pathways essential for transformation and possibly result in new therapeutic approaches.

Some proteins encoded by the vir regulon are non-essential for transformation but are known to increase transformation efficiency.

Interaction with IRS-1 and Shc are non-essential for transformation, given that NPM ALK mutants unable to interact with Shc and IRS-1 are still able to transform NIH 3T3 cells [ 115].

The inflammatory process and the accompanying immunological responses provide a microenvironment essential for malignant transformation and for the subsequent expansion of the transformed clone.

Importantly, activation of HSF1 is not only a reflection of the transformed phenotype but also appears to be essential for malignant transformation.

NIK-mediated activation of the noncanonical NF-κB pathway (phosphorylation of IKKα and subsequent limited proteolysis of NFKB2) is not essential for the transformation mechanism, given that some BIRC2/3 mutants with full transforming potential failed to activate NF-κB.