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Studies have indicated that the three-dimensional structure and the domains of HuBChE (acyl pocket, lip of the active center gorge, and the anionic substrate-binding domain) that are critical for the binding of substrate are also essential for the selectivity and binding of inhibitors including OPs.
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The presence of titanium sites was found to be essential for the development of selectivity to oxime in the liquid phase.
The heterodimeric claudin-16 and claudin-19 interaction is reported to be essential for the divalent cations selectivity of the paracellular channels at the TAL [ 5, 6].
The low Pt dispersion or aged NSR catalysts are known to give high selectivity to NH3 which is essential for the combined NSR/SCR (selective catalytic reduction) system.
This mode of interaction is probably essential for the high MMP-2 selectivity of the inhibitor because MMPs share a common architecture in the vicinity of the catalytic center, but whole structures of their substrate-binding clefts have sufficient variety for the inhibitor to distinguish MMP-2 from other MMPs [ 14].
Therefore, we conclude that the ligand positions "−4 to −7" are essential for selectivity and affinity of PDZ domain interactions, at least in the specific case of the first two PDZ domains of the PSD95 and SAP97 proteins.
Therefore, designing effective materials with high selectivity and cost-effeciency is essential for the control capturing of toxic Pb II) ions.
SACs also provide the principal inhibitory input to ON and ON-OFF direction-selective retinal ganglion cells (DSGCs) and are essential for their direction selectivity (Yoshida et al., 2001).
The proximal residues are predicted to be essential for the direct "binding," whereas the distal binding residues are predicted to determine "selectivity".
Loop E provides two residues for the selectivity filter.
Selectivity of the particular solvent to separate a mixture is essential for the optimal design of a separation process.
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