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Put together, the three studies suggest 318 proteins to be essential for the microbe.
A third FBA study (MAP), carried out by us previously for the mycolic acid pathway alone identified 15 proteins in the pathway as essential for the microbe.
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Furthermore, they would be common to a broad class of microbes so that a limited number of germ-line encoded receptors could detect all infections and be essential for the life of the microbe so that their detection could not be easily circumvented by mutation.
To be effective, MAMPS should ideally be conserved and essential for the viability of a microbe, so that a potential pathogen cannot evade host defences due to a mutation that leads to loss, or alteration, of the molecule [2].
As shown in Fig. 1, no significant removal of phenanthrene occurs at 0.1% salinity, indicating that salt concentration was essential for the growth of functional microbes in CY-1.
Many of these microbes, essential for the survival of the termite hosts, reside in a modified hindgut or fermentation sac [ 11, 12].
Nectary defense is essential for resistance against microbe infection of the entire plant.
The utilization of microbes such as bacteria and yeast is essential for the creation of sourdough and other fermented foods like wine and beer.
It is now clear that microbes present in the human gut are essential for the process of digestion in the host.
The availability of knowledge of the route of infection and critical plant and microbe factors influencing the colonization efficiency of plants by human pathogenic bacteria is essential for the design of preventive strategies to maintain safe food.
Generation of an extensive and representative microbial virtual tag library is essential for implementing the DK-MICROBE approach.
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