Obviously, surface location of KatA would be essential for the interaction with Vn.
Biochemical and structural analyses using NMR and fluorescence spectroscopy identified key amino acids essential for the interaction with H3K4me3.
Sequence and deletion analysis revealed that the interacting clones share a region containing the helicase NTP-binding motif and that this region was essential for the interaction.
In an effort to design small molecule antagonists of NPY receptors, we have synthesized a series of substituted dipeptides based on defined pharmacophores, previously identified by us and others as essential for the interaction with the peptide receptors.
The intracellular domain of OsSERK2 is essential for the interaction between OsSERK2 and the intracellular domains of XA21, XA3, OsFLS2, and OsBRI1 (Chen et al. 2014).
Of these, R46 was found to play a dominant role, and proved essential for the interaction of MIP-1 beta with both heparin and heparan sulfate in physiological salt.
The exon 2 skipping corresponding protein will miss the α1 domain, which is essential for the interaction with TfR1.
These findings suggest that an open-like configuration of the ANTXR2 MIDAS is not essential for the interaction with PA.
Interestingly, IKKβ also interacted with a kinase-dead FGFR4 (FGFR4-KD), indicathat that a functional FGFR4 kinase domain is not essential for the interaction of these two proteins.
Structural studies of Smac complexed with the third BIR domain of XIAP suggested that the IBM may be essential for the interaction with IAPs [6], [10].
Notably, besides the catalytic domain the 212 549 truncated form still contains, the KIM region which is essential for the interaction of PTP-SL with ERK2.
