Sentence examples for essential for the functional from inspiring English sources

Altogether, these data indicate that calnexin mediated ER retention of Cav3.2 channels is a key determinant of the differential cell surface expression of Cav3.2 III-IV linker splice isoforms and are essential for the functional effects of the GAERS mutation.

Unlike myosin, kinesin proteins only function in a homodimer form, suggesting that coupling between the two protomers is essential for the functional cycle of kinesin.

This is consistent with numerous studies demonstrating that the interaction between PDGFRβ and membrane proteins such as neuropilin-1, CD44, TGFβ type I receptor, and transglutaminase, is essential for the functional signaling of PDGFRβ.

Limited studies have shown that in fibroblasts or mesenchymal stem cells, the full activation of PDGFRβ requires its association with CD44, TGFβ type I receptor, neuropilin-1, or transglutaminase (Zemskov et al., 2009; Ball et al., 2010; Porsch et al., 2014), indicating that membrane proteins are essential for the functional signaling.

Vitamin D is essential for the functional immune system and should be maintained at adequate levels not only in those suffering from asthma but also in the general population.

Importantly, the correct patterning of myosin thick filaments is essential for the functional interplay with actin.

High-resolution structural information is essential for understanding the functional mechanism of these proteins.

These results provide a foundation for the cloning of bsd-pg by map-based strategy, which is essential for revealing the functional differentiation and coordination of the two cell types, and helps to elucidate a comprehensive understanding of the C4 photosynthesis pathway and related processes in maize leaves.

Knowledge regarding structure of the human cerebellum is essential for understanding the functional consequences of congenital and acquired neurological diseases of the cerebellum including sporadic and hereditary ataxias, the consequences of focal lesions such as stroke, and the cerebellar component of neuropsychiatric diseases including schizophrenia, Asperger's syndrome and autism [4] [8].

Chromosome-length haplotypes are essential for assessing the functional consequences of distantly located variants and their interactions.

Therefore, investigations of the SNPs related to functional changes of genes are considered essential for clarifying the functional genomics of organisms, including plants.