Sentence examples for essential for target from inspiring English sources

These results are consistent with previous studies which demonstrated that the miRNA-target RNA interaction is restricted to the 5'-end of the miRNA sequence and that the perfect complementarity between the miRNA 2 8 bases and the targeted RNA is essential for target recognition [30] [33].

The aims of this report are firstly to raise awareness among kineticists and pharmacologists as to why pharmacokinetic pharmacodynamic (PKPD) integration is essential for target validation (TV), optimizing development of lead compounds (lead generation [LG] and lead optimization [LO]) and scaling these to human.

According to computational and biochemical analyses [5] [7], [12], seed nucleotides are essential for target gene recognition and repression.

Experimental results show that Anidu FlbB G70 residue is not essential for target DNA recognition in vitro but seems to be necessary to increase the efficiency of the binding.

As Abu-Farah and colleagues found histone methyltransferase activity to be essential for target gene upregulation [32], we also determined the extent of H3K4 as well as H3K36 methylation in neonatal Smyd2 cKO versus control hearts, as these histone modifications are generally believed to be associated with actively transcribed genes [30] [31], [48] [49].

Generally, nucleotides 2 8 of miRNAs, termed the "seed sequence," are essential for target specificity and binding.

Internet tracking is also essential for targeting ads delivered by the big advertising networks, and without such cookies sites relying on these for revenue could be adversely affected.

Our findings support that focus on headache frequency and intensity is essential for targeting a subgroup of migraine patients at risk of developing MOH.

A lack of understanding of the molecular basis of this inhibition has been a major bottleneck in the development of next generation of drugs essential for targeting the mycolic acid component of mycobacteria.

The elucidation of the precise roles played by each of these proteases will be essential for targeting this regulatory mechanism for the development of drugs capable of blocking myostatin activity.

Within this context, being able to estimate with confidence the malaria prevalence in a given country/district is essential for targeting control/elimination efforts, monitoring the progress towards established goals, e.g. the Millennium Development Goals, and documenting achievements [6].