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Unambiguous detection and assignment of intermolecular NOEs are essential for structure determination of protein complexes by NMR.
No significant alterations were noted upon mutation of either R571 or D753 to an alanine residue and thus these amino acids do not appear essential for structure or catalytic activity.
The combination of these two features is essential for structure determination.
Three disulfide bridges formed by six cysteine residues in SnTox3 are essential for structure and function of the effector protein.
Conserved amino acid residues within a protein provide an indication of sites essential for structure and biological function.
Similar(55)
Information at the atomic level of the human telomeric intra-molecular G-quadruplex structures is essential for structure-based rational drug design.
The mode of 5′ end hook binding is similar to that observed for influenza polymerase, but here we directly observe the associated allosteric effects that are essential for structuring critical active site loops.
Using micro-computed tomography--a 3-D imaging technique that reveals inner bone structure--the researchers found that, compared to nonirradiated controls, the gamma group had 29% less spongy bone tissue, an essential component for structure and stability.
Although internal water molecules are essential for the structure and function of many proteins, the structural and physical factors that govern internal hydration are poorly understood.
Clemson, C. M. et al. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.
However, we found that unlike in c-Myb, single residue substitutions of glycines for hydrophobic residues within the Myb repeats of Cef1p, which are essential for maintaining structure of the Myb domain, did not impair Cef1p function in vivo.
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