Sentence examples for essential for stimulation from inspiring English sources

PDE4D causes degradation of the local cAMP signals produced by activated β2AR, which are essential for stimulation of contractility, and thus it weakens these pro-contractile signals hampering β2AR-stimulated contractility [ 6, 7, 15].

While ATR is suggested to inhibit phosphodiesterase and increases cellular pools of cAMP; others have suggested that PKA signaling is not essential for stimulation of aromatase in H295 cells [35].

Impairment of human T and B cell function in HSC-reconstituted IL2RγcKO genetic stocks has been attributed to the lack of expression of Human Leukocyte Antigens (HLA) in the mouse thymus, since HLA molecules are required for development of human T cells [23] that in turn, are essential for stimulation of B cells towards immunoglobulin class switching and antibody secretion [24].

However, the conserved arginine finger, essential for stimulation of the Rho GTPase activity by RhoGAPs [ 32, 54], appears to be eliminated by mutations in all cases.

These data suggest that IL-18 is produced early in the course of arthritic inflammation, indicating that it may be essential for stimulation of a proinflammatory cytokine cascade during acute inflammatory responses.

Indeed, STAT3 is essential for stimulation of RANKL and its binding element is located at −82 bp of the RANKL promoter, which is next to the C/EBPβ responsive motifs.

In a contribution to the Annals of the American Academy of Political and Social Science Mr Edward A. Filene, while disavowing Free Trade convictions, argues powerfully that a lowering of American tariffs is essential for the stimulation both of world trade in general and American exports in particular.

Delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system.

Within the oncolytic virus field, the extent of virus replication that is essential for immune stimulation to control tumor growth remains unresolved.

In this way the immune cells (macrophages) can suppress the viral infected cells or hinder their binding to macrophages by speeding up the production of cytokines, chemokines and several other growth factors essential for immune stimulation.

A series longer than 3 a. a were essential for TLR2 stimulation.