Sentence examples for essential for sensitization from inspiring English sources

We observed that Beclin 1 was essential for sensitization of the Ins(1,4,5) P3R in HeLa cells after nutrient starvation, resulting in more Ca2+ release upon stimulation by low or medium [Ins(1,4,5) P3].

The role of PIP2 as a TRPV1 inhibitor or "desensitizer" after its depletion by sequestration or PLC hydrolysis has been subsequently shown to be essential for TRPV1 sensitization (Prescott and Julius 2003).

To define the structural requirements of the molecule that are essential for thermal sensitization, we have synthesized and evaluated a series of (Z -2- N-benzylindol-3-ylmethylene)quinuclidin-3-one (9), and (Z -2- N-benzylindol-3-ylmethylenee)quinuclidin-3-ol (10) analogs that incorporate a variety of substituents in both the indole and N-benZ -2- N-benzylindol-3-ylmethylene

This enhanced synaptic transmission is essential for central sensitization.

For example, induction of autophagy is essential for steroid sensitization in childhood acute lymphoblastic leukemia cells, which requires necroptosis, a form of programmed necrosis.

Our results are in agreement with previous studies showing that regulation of the intracellular pro- and antiapoptotic protein ratio is essential for TRAIL sensitization.

45, 46 A recent report showed that CHK1, which coordinates the DDR, is essential for GEM sensitization, 19 and our data support GEM being influenced by the DDR system.

Further, JNK is also essential for activating Fas-mediated death signaling and responsible for sensitization to apoptosis induced by various drugs [35] [37].

Such injury, concurrent with allergic sensitization, appears to be essential for development of an asthmatic inflammatory response, but this is not sufficient for development of AHR.

Furthermore, sensitization to birch pollen increased the risk significantly for sensitization to both cat and dog at 8 years.

Both the sensitization and the elicitation processes are probably thresholded although this has not been rigorously demonstrated for sensitization.