In addition, this work demonstrates the usefulness of controlled environmental perturbations to uncover pathways essential for generating robustness.
To test our hypothesis that the endo-siRNA pathway is essential for maintaining robustness to temperature fluctuations, we used microfluidics to expose developing Drosophila embryos to a temperature step.
A mechanistic understanding of early organoid formation is essential for improving the robustness of these methods, which is necessary prior to use in drug development and regenerative medicine.
For example, genome-wide analyses from Drosophila to mammals have shown that promoter-proximal pausing of Pol II is a prevalent feature of many genes and that the regulated release of Pol II is essential for synchrony and robustness of their induction (Guenther et al., 2007; Muse et al., 2007; Zeitlinger et al., 2007; Levine, 2011; Zhou et al., 2012).
Precision of staining conditions is essential for the reliability and robustness of the method.
Functional experiments showed that important community functions, such as cobalamin biosynthesis, the degradation of cellulose and the oxidation of As III) are redundant in the ecosystem thus increasing the functional robustness essential for any ecosystem.
We found that, while certain core topologies are essential for producing a robust oscillator, local structures can substantially modulate the robustness of oscillations.
Finally, we envision that rigorous design techniques based on models for human-machine interaction are essential for achieving adequate performance and robustness of integral safety systems.
The parameters (gene weights) in formula (1) are estimated independent of each other, making SEP more robust than many other classifiers such as Linear Discriminate Analysis, and robustness is essential for analysis performed on independent datasets.
Knowledge of the mechanical behaviour of freeze dried biopharmaceutical products is essential for designing of products with physical robustness that will not to crack, crumble or collapse during processing or transportation.
