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Second, Tom1L1 harbours a novel clathrin-interacting motif that is not only essential for interaction with clathrin, but also important for exogenous Tom1L1 to functionally rescue endocytosis of EGFR in Tom1L1 knockdown cells.
It is essential for interaction of the IAP proteins with pro-apoptotic proteins, including the caspase family of death proteases.
Such a flexibility, which resides in the stacked HEAT repeats, is essential for interaction with RanGTP or with NPCs.
Typically, tubulin inhibitors that bind to the colchicine binding site bear the trimethoxyphenyl (TMP) moiety which is essential for interaction with tubulin.
Using domain dissection and cross-linking mass spectrometry, we identified a unique region of Pih1p that is essential for interaction with Rvb1p/Rvb2p.
The RHT-CLA ligands were designed and characterized for ADME/Tox features, interaction with HSF1 DNA binding domain and their pharmacophoric features essential for interaction.
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Future studies should comprehensively examine the metal bioavailability in aquatic sediments, because this factor is essential for interactions between the abiotic and biotic components of an aquatic ecosystem [2].
ATP processing by MutL is essential for interactions with MutH and UvrD [4], [13].
This is perhaps not entirely surprising, since we were able to demonstrate that regions of ATG16L1 essential for interactions with ATG5 and other ATG16L1 moieties lie upstream of amino acid 300, which is affected by the identified functional SNP.
Is the ankle site essential for interactions?
Secreted proteins are essential for interactions with the environment, particularly for sessile organisms such as fungi.
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