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The selection process ensures that, in functional clones, amino acids essential for function will be conserved relative to non-essential sites.
Finally, phylogenetic analysis revealed that ERK1 amino acids sequences evolve faster than ERK2's likely due to genomic factors, including a large difference in gene size, rather than from functional differences since amino acids essential for function are kept invariant.
The inability of a canonical Myb repeat to substitute for Cdc5-D3 in cells suggested that the functional surfaces present on Cdc5-D3 aressentialal for function and cannot be replaced with a structural Myb domain.
In some cases these modifications are known to affect structure and are essential for function.
Suppose a part gets added to a system merely because the part improves the system's performance; the part is not, at this stage, essential for function.
The Hsp90/Cdc37 chaperone system is essential for function of normal and neoplastic cells.
RNAs adopt diverse folded structures that are essential for function and thus play critical roles in cellular biology.
Deletion of the last 9 tail residues of C-TIMP-2 in P175L abrogated the inhibitory activities of the peptide showing that these residues were essential for function.
We propose a general, structure-based strategy to reduce the probability of drug resistance by designing inhibitors that interact only with those residues that are essential for function.
The WF finger motif that is essential for function in human Atg101 is sequestered in a hydrophobic pocket, suggesting that the exposure of this motif is regulated.
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Over time, we hope a network like this can shift behaviors and build the trust that is essential for functioning, accountable government.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com