Good muscle function and healthy bones are essential for fast rehabilitation and positive outcome after orthopaedic surgery, as well as good physical function [4, 5].
This is essential for fast image sampling and the minimization of both focal drift and photobleaching due to scanning [43] [45].
Early functional investigations pointed out that IA is typically involved in setting the interspike interval [22], while IDR is essential for fast repolarization of action potentials and consequently contributes to repetitive firing [22], [26].
VGSCs can rapidly cycle through the resting, open and inactivated states, allowing neurons to fire the high-frequency trains of action potentials that are essential for fast neurotransmission.
Schwann cells not only reconstitute myelin, which is essential for fast neural action potential propagation, but also provide physical guidance (bands of Büngner) and trophic support for axonal regeneration.
More recent reports have implicated RIM1/2, which contains a PDZ binding domain, (Kaeser et al., 2011), as a channel scaffold molecule (Han et al., 2011) and is essential for fast transmitter release.
Overall, the initial clinical validation step in our biomarker development procedure has allowed us to answer two critical questions for the potential applicability of the biomarker in clinical practice; hence, in our opinion, this step is essential for fast streamlining of the biomarker validation process.
Indeed, most of the genes within this cluster were found downregulated in tumors compared to surrounding tissues with the exception of the gene encoding for the GABA type-A receptor alpha5 subunit, GABRA5, essential for fast inhibitory neurotransmission and critical in brain function [ 37].
Here, we show that posttranslational modification of the active zone protein Rab3-interacting molecule 1α (RIM1α) by the small ubiquitin-like modifier 1 (SUMO-1) functions as a molecular switch to direct these interactions and is essential for fast synaptic vesicle exocytosis.
It is 14.2 to 16 hands high, with sturdily muscled hindquarters, essential for the fast departure required in short races.
