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Study of the learning and memory signal transduction pathway is essential for elucidation of nootropic mechanisms.
Thus, characterization of the MTB-specific T cells, especially their TCR gene usage [ 50], is essential for elucidation of the pathogenesis of active TB or LTBI and for the development of individualized treatment.
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Understanding the contribution to each of these intracellular pathways is essential for the elucidation of mechanisms that drive pathophysiology.
Understanding the role of stromal fibroblasts and inflammatory cells and their interaction with oncoprotein expression is essential for the elucidation of lung cancer pathogenesis.
The characterization of Aβ assemblies is essential for the elucidation of the mechanisms of Aβ neurotoxicity, but requires large quantities of pure peptide.
Morphological analyses of the microcephaly by autopsy are essential for the elucidation of pathophysiological roles of SIL1 mutations in neurodegeneration of MSS.
Therefore the analysis of protein-protein interactions, either in vitro, using for example protein arrays, co-immunoprecipitation or affinity chromatography, or in vivo by two-hybrid assays is essential for the elucidation of biological processes and/or networks.
As pointed out by Gutfreund [23], "rapid reaction techniques are essential for the elucidation of the chemical mechanism of enzyme reactions" and, in particular, "the algebra of steady state kinetics is no substitute for the direct observation of the formation and decomposition of intermediates".
RNAi has emerged as an essential laboratory tool for elucidation of gene function and has rapidly been adopted for functional genomics, pathway analysis and target validation.
Since such soils can reach a depth of several meters a better understanding of the processes involved in the humification of its SOM is essential for an improved elucidation of the impact of the hot and humid conditions of subtropical regions on global C cycling.
Nevertheless, correct assignment of boundaries of the protein domains is essential for the efficient elucidations of protein function and evolutionary mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com