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Since Sec residue is contained in the active site of GPx, Sec is thought to be essential for activity [24].
Moreover, Ligand based pharmacophore modeling of these Schiff bases was conducted to evaluate the common features essential for activity and the hypothetical geometries adopted by these ligands in their most active conformers were undertaken.
Here, we also show that the nuclease domain of G2P is not active in isolation, suggesting that interactions with the ATPase domain are essential for activity.
The formation of stable Cu2Cl(OH)3 was essential for activity and stability of the catalyst.
It was noted that carbamate and N,O-aminal groups were essential for activity.
Quantum chemical studies were also performed on 10f to understand the structural features essential for activity.
As for RNF125, one of the ZnFs was found to be essential for activity as well as for solubility of the RING domain.
This confirmed that the main part of rfhSP-D adopts the 57 kDa trimer conformation that is essential for activity (Fig. 8c and Supplementary Fig. 10).
Quantum chemical studies were also performed on the target compound 3c to understand the structural features essential for activity.
Quantum chemical studies were carried out on these compounds to understand the structural features essential for activity.
The D614 carboxylate appears to ion pair with the amino group of homocysteine and is essential for activity.
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