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This acetylation of ATM within its regulatory domain is essential for activating ATM's kinase activity.
These polypeptide products, called saposins (Saps, sphingolipidhydrolase activating proteins), are essential for activating a set of lysosomal sphingolipid hydrolases [ 54].
Thus, activation of Raf is essential for activating the Raf/MEK/ERK signaling pathway and many functions attributed to Raf activation are executed by the subsequent activation of MEK and ERK.
Those abilities may be needed to resolve ambivalence toward alcohol addiction and to apply "processes of change", which are essential for activating the desire to change problematic behavior.
The activity tests for high concentration (30%, v/v) of N2O decomposition demonstrated that the BaIrxFe1−xAl11O19 hexaaluminates exhibited much higher activities and stabilities than the Ir/Al2O3-1200, and the pre-reduction with H2 was essential for activating the catalysts.
Additionally, real time RT-PCR analysis suggests that flow induces Wnt5a and Ror2 upregulation, both of which are essential for activating the small GTPase, RhoA, upon flow exposure.
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This means that production of c-di-GMP by YdaM somewhat contributes to but is non-essential for activating MlrA to drive csgD transcription, that is, YdaM may activate MlrA by direct interaction.
We previously found that ATP was released extracellularly by PMNs through pannexin-1 (PANX1) hemichannels and that autocrine feedback through the P2Y2 receptor, one of eight P2Y G protein-coupled receptors, is an essential mechanism for activating PMNs [5, 6].
PGRP-SA is an essential component for activating the Toll pathway in Drosophilia [ 63].
It was highlighted that immune response may be boosted up by baicalin treatment via increased expressions of IFN γ and IL12, which are the essential factors for activating all types of acquired immune response.
The cytoplasmic domain of the GHR is essential not only for activating the GHR but also for triggering internalization of the hormone receptor complex [ 10].
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