Synthetic lethal interactions can reflect, for instance, non-essential elements of compensatory pathways that converge on the same essential endpoint function.
It is essential that endpoints in studies of CRC are clearly defined as this will increase the comparability of studies.
The role of biomechanics in this process will be to identify and quantify the structural mechanical endpoints essential for appropriate heart valve leaflet function, while guiding investigators prior to and during clinical evaluation.
As the number of agents available grows, and as new treatment strategies emerge, it is essential that the endpoints we use to assess efficacy are sufficiently meaningful and sensitive enough to detect changes that are often subtle.
This improvement was not associated with an increase in the proportion of motile sperm (p = 0.12), providing further evidence that it is essential to evaluate endpoints other than sperm survival and motility when optimizing cryopreservation methods.
Since the treatment of patients with intermittent claudication (IC) is primarily aimed at improving their walking ability and health-related quality of life (HRQL), it is essential that these endpoints are measured when evaluating treatment.
MFS is an iterative backward stepwise elimination method with the purpose of minimizing the gene set (i.e., removing uninformative genes while retaining these essential to the endpoint studied) and thus generating a signature of smaller size and improving predictive power based on the resultant feature set.
In gene transfer trials, it is essential that meaningful correlative endpoints are employed in order to correlate the employed doses with biological effect and select the most appropriate dose for phase II setting.
In this study, we designed an apparatus that allows for the simultaneous investigation of three essential behavioral and physiological endpoints in Daphnia, including ventilation, food uptake rate, and heart rate.
In the design of chemical processes, such as catalytic cracking of bitumen and heavy oil, the knowledge of phase behavior at the critical endpoint is essential.
