FET-proteins are also involved in neurological diseases with FUS and TAF15 mutations identified in familial amyotrophic lateral sclerosis (ALS) [ 5– 8], frontotemporal lobar degeneration (FTLD) [ 9] and essential tremor disorders [ 10].
Specific medical comorbidities, including asthma, autoimmune diseases, inflammatory/atopic disorders, mental health problems, essential hypertension, haematological disorders, musculoskeletal disorders, and infections, were found to be associated with a higher risk of dying from the conditions included in this study.
This phenotype, reminiscent of the myeloproliferative disorder essential thrombocythemia, adds to a growing body of evidence linking c-Myb deregulation to hematological disorders.
Further, the V617F mutant of JAK2 is the causative mutation in approximately 50% of patients with the myeloproliferative disorder, essential thrombocythemia (ET), which is characterized by an increase in platelet count [11−13].
Final diagnoses in suspect cases were PD (115), essential tremor/other tremor disorder (12), no neurologic diagnosis (5), dystonia (2), multiple system atrophy (2), and atypical parkinsonism not fulfilling any diagnostic criterion (1), the latter three cases subsequently termed "atypical parkinsonism".
According to the International Classification of Headache Disorders, the essential diagnostic criteria of PH disorders are based on the presence of specific clinical features and the absence of decisive pathological or radiological findings.
Trombocytosis are divided into primary or autonomous, in the course of myeloproliferative disorders (essential thrombocythemia, polycythemia vera, chronic myelogenous leukemia) and secondary or reactive.
The analytic variable 'maternal medical condition' included ICD-10 coded conditions known to be risk factors for severe maternal morbidity 4 13–15 such as cardiac disease, pre-existing diabetes, epilepsy, essential hypertension, haematological disorders, past thrombotic event (deep vein thrombosis, stroke, pulmonary embolism) and severe mental illness.
Therefore, it is essential to consider these disorders in the differential diagnosis of bipolar disorder or schizophrenia so that the correct diagnosis can be established and the families counseled about the increased recurrence risk.
Also, child right law that protects the interests of children with childhood autism and other developmental disorders is essential to ensuring that the rights of children with developmental disorders in this environment are not compromised as advocated by the 1991 African charter and the 1990 United Nations convention on the rights of the child [ 15].
