Sentence examples for essential differentiation factor from inspiring English sources
IL-6 is a pleiotropic cytokine with a variety of functions, but of importance for this study, IL-6 is an essential differentiation factor for Th17 cells [37], [38].
Given that RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis, we tested the hypotheses that inhibition of RANK expression by RNA silencing would reduce the number of osteoclasts and the activity of bone erosion.
Thus, in the present study, we focused on by possible functional role of myeloid differentiation factor 88 (MyD88), an essential adapter protein for TLR/interleukin (IL -1 receptor sIL -1ing [8], [9], in metabolic disease.
In the study by Kleinridders et al [ 37], the critical involvement of TLR4 signaling was demonstrated through brain-specific deletion of myeloid differentiation factor 88 (MyD88) – an essential signaling adaptor for TLR pathways to activate downstream proinflammatory signaling mediated by IKKβ/NF-κB or JNKs [ 212; 212].
Growth differentiation factor.
The first indispensable factor for browning is peroxisome proliferator-activated receptor γ (PPARγ), an essential transcription factor for differentiation and survival of both brown and white adipocytes (22, 54– 54).
Runx2 is an essential transcription factor in osteoblast differentiation [ 34] and bone sialoprotein is a late marker for osteoblast differentiation found during the mineralization process of osteoblasts [ 35].
As c-Jun is an essential transcription factor for osteoclast differentiation in vivo, blockade of the JNK and c-Jun pathway by SP600125 suppresses osteoclast differentiation.
This expression pattern was similar to RUNX1, one essential transcription factor for megakaryocyte differentiation.
Cbfa1, the essential transcription factor for osteoblast differentiation, was shown to play an important role in AMBN transcription [ 34].
Runx-2 is the essential transcription factor orchestrating the differentiation programme in osteoblast precursors (Harada and Rodan, 2003).
