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Numerous molecular studies over the years have presented p53 as an essential controller of cellular and genome integrity [1].
STIM1 has been identified as an essential controller of SOCE [5], [6], but reports on the role of STIM2 in the SOCE process have been inconsistent.
However, Rac is also an essential controller of cytoskeletal re-arrangements in many cells [36], and its perturbation leads to large-scale anatomical defects during Purkinje neuron maturation [37].
It is thus the essential controller of HOG pathway activity, and variations in its concentration could compromise fitness.
Interestingly, the nutrient-sensing TOR pathway that is activated by insulin, growth factors and nutrients is an essential controller of cell growth.
Sirolimus is an inhibitor of mammalian target of rapamycin (mTOR), a kinase enzyme which is an essential controller of cellular and organism growth that integrates nutrient and hormonal signals, and regulates multiple cellular processes.
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Remarkably, TOR is structurally and functionally conserved from yeast to human (including worms, flies, plants and mice) as an essential, central controller of cell growth [ 1].
It is shown that robustness constraints are essential, and that controller design based on maximization of performance criteria without robustness constraints give poor controllers.
As friction models are needed to diagnose abnormal valve operation or to compensate such undesirable effects, process models play an essential role in controller design.
Model-based controllers are often essential for effective control of nonlinear processes.
Re-tuning the dynamic gains of FBL controller is essential under such conditions.
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