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Zotenko et. al. found that essentiality is due to the involvement of hubs in essential complex biological modules, groups of densely connected proteins with shared biological function that are enriched in essential proteins [ 12].
Condensin II is another essential complex for the amelioration of high-B-induced DSBs7.
It stems directly from rural living conditions, in which the management of human waste is essential, complex and demanding.
While this could explain the correction of mitochondrial function in mitochondria lacking the complex IV assembly factor Cox15, it does not explain the improvement observed in mice where the essential complex I subunit Ndufs4 is deleted15.
In contemporary architecture, this essential, complex and ambiguous rapport is defined by a multiplicity of trends, design directions and experimental forays into the sciences and arts.
The ribosome is an essential complex macromolecule responsible for protein synthesis in all organisms.
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We hypothesized that bacterial proteins interact with human proteins with high degree and centrality, since pathogens may have evolved to control and disrupt essential complexes and pathways governing the host response.
If redundancy explains the presence of nonessential genes within essential protein complexes, then essential complexes should be enriched for negative genetic interactions.
There are exceptions to this rule, however, that is, nonessential genes in largely essential complexes and essential genes in largely nonessential complexes.
that is, why are there nonessential subunits in largely essential complexes and why are there essential subunits in largely nonessential complexes?
Furthermore, we found that nonessential genes in otherwise essential complexes frequently exhibit negative genetic interactions with another member of the same complex.
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