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Here we have shown visual evidence for a highly orchestrated chromatin decondensation of essential clusters of snoRNAs during neuronal maturation.
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In order to test the relevance of all non-essential clusters for a chassis, each GRS was first characterized for changes in biological fitness during growth on defined CGXII medium.
In syndecan-2, Tyr10 and another, more C-terminal tyrosine residue is phosphorylated by the EphB2 receptor tyrosine kinase, and this phosphorylation is essential for clustering of syndecan-2 and spine formation in hippocampal neurons (Ethell et al. 2001).
Here we describe the Cluster of Essential Genes (CEG) database, which contains clusters of orthologous essential genes.
Clusters of essential genes are known to reside in low-recombination regions (Pal and Hurst 2003).
Similar to starvation-repressed gene clusters, clusters of essential genes are almost completely absent from telomere-proximal regions (Fig. 3).
Physically clustered genes may have shared regulatory regions, common expression pattern, and chromatin-level regulation, or they may represent clusters of essential genes [ 38].
Clusters of essential genes are known to be in regions of the genome that are characterized by a lower recombination rate [ 33].
CEG allows users to paste or upload sequences, and BLAST the query sequences against all clusters of essential genes contained within the database.
Essential genes and essential gene clusters more frequently overlap clusters of starvation-repressed genes (Fig. 4D).
Similar to starvation-repressed genes, essential genes and essential gene clusters often map between clusters of genes induced by starvation or in other regions of chromosomes that harbor very few starvation-induced or potentially silenced genes (Figs. 3 and 4E).
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