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The interplay of the proteostasis network with other essential cellular functions such as cilia and vesicle transport is only beginning to be unraveled [3].
Activation of this pathway plays a pivotal role in essential cellular functions such as survival, proliferation, migration and differentiation that underlie the biology of human cancer.
These in turn lead to a decrease in essential cellular functions such as protein translation or mitochondrial respiration and the induction of innate immune responses that may be specific to the cellular deficit induced.
On one hand, RBPs assist the processing and assembly of non-coding (nc) RNAs into RNP complexes, which mediate essential cellular functions such as splicing and translation [1].
The ubiquitin/proteasome system (UPS) is known to mediate intracellular protein degradation for misfolded, damaged and key regulatory proteins involved in various essential cellular functions such as transcription, stress response, cell cycle, cell differentiation and DNA repair [28].
Interestingly, the above non-conserved amino acid changes predominantly occurred in proteins that function in the essential cellular functions such as replication, transcription, translation, ATP and cell wall synthesis.
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When examining the pathogens under study (Table 3), some helicases that are essential to cellular functions, such as DnaB and UvrD, are distributed across all the organisms.
As these cofactors are essential for cellular functions such as carbon metabolism, DNA repair, and energy production, their abundances give credence to the notion of ancient origins of riboswitches.
Actins are essential for cellular functions such as motility, the maintenance of cell shape and polarity, cell division and cytokinesis, vesicle and organelle movement, cell signalling as well as the establishment and maintenance of cell junctions, and regulation of transcription [ 38].
Protein-protein interactions (PPI) play essential roles in cellular functions, such as DNA transcription, signal transduction, or cytoskeleton formation.
Not all biological catalysts are protein enzymes; RNA-based catalysts such as ribozymes and ribosomes are essential to many cellular functions, such as RNA splicing and translation.
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