Sentence examples for essential cellular functions and from inspiring English sources
Our assembly of a global genetic network composed of hundreds of thousands of genetic interactions highlights the power of combinatorial genetics for identifying pathways, delineating how they work together to control essential cellular functions, and mapping a functional wiring diagram for the cell (Costanzo et al. 2010).
Mitochondria fulfill a number of essential cellular functions, and it is recognized that the strict regulation of the structure, function and turnover of these organelles is an immutable control node for the maintenance of neuronal and vascular homeostasis.
Autophagy has been implicated in a variety of essential cellular functions, and we have established an important role for autophagy in maintaining mitochondrial function by supporting essential protein synthesis, and mitochondria dysfunction is the major cause of starvation-induced cell death in autophagy-defective mutants.
Mitochondria integrate extracellular signals, carry out essential cellular functions, and determine neuronal survival and death.
These proteins are critical for many essential cellular functions and constitute 60 to 70% of current drug targets [ 1].
Genes expressed in a large number of tissues may encode essential cellular functions and thus would evolve more slowly.
Transport across the nuclear envelope is also an essential cellular function and is intimately linked to many degeneration processes that lead to disease.
DOI: http://dx.doi.org/10.7554/eLife.02978.012 Small GTPases are guanine nucleotide binding proteins that control a variety of essential cellular functions (Vetter and Wittinghofer, 2001; Cherfils and Zeghouf, 2013).
These pathological deposits the amyloid plaques of AD and the drusen of AMD demonstrate some compositional similarity, engender a pro-inflammatory response and impair essential cellular functions such as trafficking and secretion.
In addition to energy supply, mitochondria integrate extracellular signals and carry out essential cellular functions determining neuronal survival and death.
Many miRNAs are up-regulated in response to cellular stress [ 9] and can modify essential cellular functions of proliferation, differentiation and programmed death [ 10– 10].
