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Protein complexes are essential cellular functional units in which several proteins work as parts of assemblies.
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Our assembly of a global genetic network composed of hundreds of thousands of genetic interactions highlights the power of combinatorial genetics for identifying pathways, delineating how they work together to control essential cellular functions, and mapping a functional wiring diagram for the cell (Costanzo et al. 2010).
Several essential cellular functions of mitochondria depend on a high degree of functional interaction between the nuclear and mitochondrial genomes.
This is consistent with the essential cellular functions of DNA replication machinery, and is further suggestive of functional domains underlying these specific single mutations.
Through functional annotation analysis, our results indicated that ceRNA regulation is highly associated with essential cellular functions and diseases including cancer.
Adenosine nucleotides provide energy for many essential cellular functions.
Mitochondria participate in a large number of essential cellular functions.
Given the importance of the Hsp70 family in essential cellular functions and also that Hsp70 is a potential therapeutic target for a variety of human diseases, it is important to understand Hsp70s essential and non-essential roles within the cell and to characterize the functional difference between members of this chaperone family.
Virtually all genes fulfilling essential cellular functions are early replicating.
The main cytotoxic effect results from interaction of silver ions with thiol (sulfhydryl) groups and other functional groups in enzymes and proteins, disrupting essential cellular processes such as respiration and the establishment of proton motive force (Jung et al. 2008).
Mitochondrial metabolism links energy production to other essential cellular processes such as signaling, cellular differentiation, and apoptosis.
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