Coast Guard cutters cruised ports and waterways on the Atlantic and Pacific coasts, where only essential cargo vessels were allowed to dock.
The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based kinesin motor transport to deliver essential cargo into axons and dendrites.
Feeder carriers were considered to be significant since the availability of efficient feeder links is essential for cargo movements between the ultimate origins and destinations in hub and spoke networks.
The C-terminal part of the tail forms a globular domain, which is essential for cargo binding and/or interaction with binding partners as well as with PIP2-containing liposomes (Sweeney and Houdusse 2007, 2010; Chibalina et al. 2009).
SNAREs are essential vesicle cargo proteins, because without them vesicles would be unable to fuse with their targets, but with the exception of VAMP4 (vesicle-associated membrane protein 4), which has a dileucine motif that binds to AP-1 [ 20], most SNAREs lack conventional sorting signals.
Identification of Unc119 cargos essential for neuronal survival and analysis of their localization in C9orf72 patients will be necessary to determine functional Unc119 inactivation and its correlation to neurodegeneration.
In addition to carriers and adaptors like importin-α, nucleoporins, also called nups, are essential to move cargoes across the nuclear envelope.
Surprisingly, the small GTPase IFT27, a member of the IFT-B complex, turns out to be essential for retrograde cargo transport in Trypanosoma brucei.
Kinesins are essential for transporting cargo such as membrane vesicles, organelles and RNA molecules along microtubules in an ATP-dependent manner.
We also found that intracellular Aβ oligomers significantly impaired the intracellular transport of BDNF, mitochondria, and recycling endosomes: cargoes essential for synaptic maintenance.
