Twice in the previous year, this convoy with its essential cargos of iron ore, nitrates, and other chemicals—had been raided by German cruisers and destroyers, with the loss of 15 allied freighters.
Feeder carriers were considered to be significant since the availability of efficient feeder links is essential for cargo movements between the ultimate origins and destinations in hub and spoke networks.
The C-terminal part of the tail forms a globular domain, which is essential for cargo binding and/or interaction with binding partners as well as with PIP2-containing liposomes (Sweeney and Houdusse 2007, 2010; Chibalina et al. 2009).
SNAREs are essential vesicle cargo proteins, because without them vesicles would be unable to fuse with their targets, but with the exception of VAMP4 (vesicle-associated membrane protein 4), which has a dileucine motif that binds to AP-1 [ 20], most SNAREs lack conventional sorting signals.
Surprisingly, the small GTPase IFT27, a member of the IFT-B complex, turns out to be essential for retrograde cargo transport in Trypanosoma brucei.
Kinesins are essential for transporting cargo such as membrane vesicles, organelles and RNA molecules along microtubules in an ATP-dependent manner.
Motors have a drastic influence on the spatial organization of actin and MT systems (see also Sections 2.2.2 and 3.2) and are further essential for intracellular cargo transport and cellular force production.
In addition to carriers and adaptors like importin-α, nucleoporins, also called nups, are essential to move cargoes across the nuclear envelope.
We also found that intracellular Aβ oligomers significantly impaired the intracellular transport of BDNF, mitochondria, and recycling endosomes: cargoes essential for synaptic maintenance.
