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This new understanding of the cellular origin and molecular induction of CCS tissues during embryogenesis may provide the foundation for tissue engineering, replacement and repair of these essential cardiac tissues in the future.
GATA4 works in combination with other essential cardiac transcription factors as well, such as Nkx2-5 and Tbx5 [ 13].
A promising approach for the identification of essential cardiac regulators whose mutations may be linked to human CHD, is the molecular and genetic analysis of heart development.
Coronary artery disease is the essential cardiac manifestation of diabetes mellitus type 2 and is responsible for the predominant number of deaths.
Hypertension management at commune level was an important but challenging step in moving essential cardiac care services into primary health care sectors in Vietnam.
ErbB4 null mice, with the essential cardiac function supplied by transgene-driven expression of ErbB4 cDNA exclusively in the heart, survive past birth and are defective in lactation, but undergo normal development at puberty [ 24].
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In the heart, apoptosis is essential for cardiac development such as formation of cardiac valves and outflow tract [3].
BAF60c is essential for cardiac and skeletal myogenesis and promotes the activation of cardiac and skeletal muscle-specific genes, including muscle-specific miRNAs (Lickert et al., 2004; Ochi et al., 2008; Mallappa et al., 2010).
In addition, TAK1, which is immediately upstream of NLK is essential for cardiac differentiation in P19 [71], and TAK1 [72] and TAB1[73] mutants show defects in cardiac morphogenesis.
We show that cell-cycling post-gastrulation is not essential for cardiac differentiation in Xenopus embryos, and conversely that some cells can express markers of cardiac differentiation even when still in cycle.
Deformation and wall-thickening of ventricular myocardium are essential for cardiac pump function.
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