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In HR repair, an essential bottleneck step is the processing (resection) of double-strand breaks by nuclease enzymes to produce single-stranded (ss) DNA.
In the use of an eco-friendly and ubiquitous element, Si as thermoelectric material, high κ value in bulk Si is the essential bottleneck to achieve high dimensionless figure of merit.
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Clearly, these costs are only essential in bottleneck situations and even then impossible to measure.
The WHO report states "[d]eveloping capable, motivated and supported health workers is essential for overcoming bottlenecks to achieve national and global health goals" [[ 1]:xv].
According to the WHO, developing capable, motivated and supported health workers is essential for overcoming bottlenecks to achieve national and global health goals [ 4] and UNFPA stated that "Continuing education is essential for professional responsibility, and it is also a path to career opportunities for those who want to become educators, supervisors and researchers" [ 7] (p. 19).
Our analysis identified bottlenecks across seven health system building blocks for essential care during childbirth and the immediate postnatal period.
The exploration of efficient, stable and cheap water oxidation catalysts (WOCs) is essential for overcoming the bottleneck of water splitting.
An essential feature of this bottleneck is that the infants harbored a less diverse HIV-1 population than their chronically infected mothers.
Furthermore, non-hub/bottleneck (NH-B) nodes were also identified due to the essential nature of the bottleneck nodes in the network dynamics.
RTPCR and full-length sequencing remain essential in resolving the bottleneck between numerous candidate novel transcripts inferred from high-throughput sequencing and the small fraction that can be validated.
One essential broken tool can bottleneck the rest of your work flow if you can't proceed without it!
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CEO of Professional Science Editing for Scientists @ prosciediting.com