Sentence examples for essential binding sites from inspiring English sources

Prior to making chemical modifications to the hit fragment, we first identified its essential binding sites by utilizing the hit fragment's substructures.

aureus agents that block essential binding sites or generate local innate immune activity.

The Slit2 promoter may have essential binding sites for the β-catenin-TCF complex.

To capture the essential binding site features of a promiscuous drug, we developed a method to construct its PPE (see Section 2 for details).

In [ 28], an essential binding site from ptc1 promoter, with a single substitution from the consensus GBS sequence, was mutated to investigate the effect of change bases in the expression of a reporter gene, resulting in different non-consensus and low affinity Gli binding sites that could lead to transcriptional activation.

We found no evidence of an essential Scc3 binding site within the N-terminal half of Scc1 [44], although we presently cannot exclude non-essential binding sites.

An essential ETS1 binding site [18], [19] and a CREB site [20], [21] is found in the primate-specific MER39 that also encodes exon 1a.

One of these families, Group II XRs, lack some essential keto-carotenoid binding sites and have been described as being devoid of the carotenoid antenna characteristic of group I [ 51].

They are essential DNA-binding sites of the plasmid-specific replication initiator protein and have additional replication and copy number control properties [ 86].

The Hsp family has two essential ATP-binding sites and belongs to a larger class of AAA+ chaperone-like ATPases, which are involved in the assembly, operation, or disassembly of protein complexes [ 70].

Water is an essential part of protein binding sites and mediates interactions to ligands.