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It was the orchestra, with agile harpsichord and cello continuo, that offered the essential binding force.
"It's a very important thing for us to show right at the entrance, because we are the Islamic department and Islam is an essential binding thread throughout the installation".
Our objective was to develop small peptides based on essential binding elements of the natural protein inhibitor, Tendamistat.
Prior to making chemical modifications to the hit fragment, we first identified its essential binding sites by utilizing the hit fragment's substructures.
The presence of a pyrimidine base in thymine, cytosine and uracil, which are the essential binding blocks of nucleic acids, DNA and RNA is one possible reason for their biological and therapeutical activities.
Using a series of molecular dynamics simulations and docking protocols, we identified essential binding interactions exerted by all three classes of drugs, among which, a π sulfur interaction (between a His287 and a sulfur-containing heterocycle) was the most important.
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We found no evidence of an essential Scc3 binding site within the N-terminal half of Scc1 [44], although we presently cannot exclude non-essential binding sites.
The N-terminal sequence contains an approximately 60 amino acids long dinucleotide-binding motif essential for binding of FAD (Dailey and Dailey 1998; Dailey et al. 1995).
The CACC sequence within this stem region is essential for binding since its substitution also destroys binding although the internal stem base pairing is retained.
Fas_86R was previously deemed essential for binding to FasL, whereas mutation of Fas_81F reduced binding.
The presence of AnxA2-Val3 is essential for binding to S100A10 since its substitution leads to substantial loss of binding.
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