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In Table 4 and 5, there are ~30% of genes in the co-targets set are essential based on the essentiality information retrieved from TB [ 70] and DEG v5.0 database [ 71].
While much digital ink has been spilled on the topic of how to unleash innovation in organizations, here are three ingredients of innovation that I've observed are essential based on my experiences.
The criticality of offshore drilling safety appears more essential based on the stated statistics by the head of the International Energy Agency of the OECD.
The four Arabidopsis poly(A) polymerase genes were found to be essential, based on genetic analysis of T-DNA insertion mutants.
This could explain the result with the STM strains of the argS gene since the arginyl-tRNA synthetase appears to be essential based on our failure to obtain viable argS deletion mutants.
The Corynebacterium glutamicum ortholog (NCgl0187) could not be deleted by Meniche and colleagues [9] and the M. tuberculosis ortholog (Rv3790) is thought to be essential based on a lack of insertions in transposon mutagenesis experiments [14], however, in both cases, direct experimental evidence of essentiality is lacking.
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Recently, many computational methods have been proposed to identify essential proteins, based on the features of essential proteins.
Many of these domains of unknown function are found to be essential DUFs based on the presence of essential proteins in these families.
Washington considers Okinawa well situated to provide an essential base of operations in a region where security concerns -- underscored by the standoff with China -- are gaining importance.
Five-spice powder – a mix of star anise, Szechuan peppercorns, fennel seeds, cinnamon stick, and clove – is one of the essential bases to Chinese cooking.
This could have a huge impact as innovation has played a critical role in the unearthing of new open data initiatives, with a number of businesses having emerged over the past couple of years, such as transport app Citymapper, consultancy firm Geolytix, data analysts Spend Network and food marketplace Foodtrade, using public data as an essential base for their core proposition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com