Kuhn kept things under control there by denying that normal scientists seek essential innovation, for, as indicated above, major, unexpected discoveries threaten the extant paradigm and hence threaten crisis and revolution.
Phospho-regulation of Spc110 is not absolutely essential for viability as indicated by the growth of spc110 5A cells.
The K0.5 values and the Hill coefficient of the essential ligands were determined as indicated previously.
Pro-1, Arg-70, and Arg-73 are essential residues for the process as indicated by the observation that the enzymes with the corresponding alanine mutations are not covalently modified by either enantiomer.
Dirac's attempt to prove the equivalence of matrix mechanics and wave mechanics made essential use of the delta function, as indicated above.
Wnt signaling is instrumental in intestinal homeostasis, as indicated by the essential role of Wnt3, R-spondin, and downstream β-Catenin/TCF transcription regulators in stem cell maintenance, and Lgr5 is actually a target gene of Wnt signaling (Korinek et al., 1998; Kim et al., 2005; Sato et al., 2011).
As indicated above, an essential part of the model is the specification of relationships such that the model can be fitted by using standard animal breeding software.
However, this region could impart an essential function of protein-protein interaction, as indicated by the dominant-negative effect in flies or ESCs overexpressing arjC.
Endogenously tagged GIP-2 fully supported the essential functions of the γ-tubulin complex, as indicated by the normal development of worms homozygous for the insertion.
As indicated, long term ground surface elevation data is essential in subsidence modeling.
