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This phenotype suggested that EF4 plays an essential and specific role in increasing the fitness of E. coli under unfavorable to extreme environmental conditions, where it ensures appropriate/adequate regulation of protein synthesis.
Peptidoglycan is an essential and specific component of the bacterial cell wall and therefore is an ideal recognition signature for the immune system.
The conservation of DRP-1β and ZIPk and their gene organization across vertebrates, perhaps even from the very emergence of this subphylum, excludes complete redundancy and indicates some essential and specific roles for both kinases.
If, on the contrary, they are both essential and specific for the target domains, then the statistical biases within this region in natural ligands should be analogous to, or at least reminiscent of, the amino acid frequency patterns observed within the same positional window in artificial ligands.
One of the essential and specific functions of mTORC1 is the regulation of cell size.
Our work also suggests an essential and specific role of CaMid1 in caspofungin tolerance.
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As the SHF has not yet been genetically defined, additional genes essential for and specific to SHF development likely await discovery.
The VEGF system has been conserved from zebrafish to man as a signalling pathway that is essential and rather specific to the vascular and haematopoietic systems.
The other essential and highly specific player in the control of csgD and therefore csgB::lacZ is the transcription factor MlrA (Brown et al, 2001; Weber et al, 2006).
Since in contrast to NSP1, RAM1 was not described to be required for the transduction of Nod-signals [ 43, 45, 46], RAM1 is currently regarded both as an essential and a specific component of Myc-signaling.
We show that domains I and II of the GBV-B 5'NTR contain essential and virus-specific RNA replication signals, whereas domain III, which is essential for virus translation, does not play a critical, virus-specific role in RNA replication.
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