Sentence examples for essential alterations in from inspiring English sources

As even minor temperature shifts strongly influence the growth and development in salmonids and cause essential alterations in life history patterns, any long-term non-adaptive variation in response to thermal conditions is likely to have important consequence on individual physiology and fitness [49].

Neoplastic overgrowth involves essential alterations in cell physiology, loss of cell proliferation control and resistance to cell death.

These essential alterations in cell physiology are, amongst others, achieved by the constitutive activation of oncogenes and the loss of tumor suppressor gene (TSG) function.

In general, the contributions of MAPK, CREB, and PTEN to the cell circuitry involved in carcinogenesis are also comprehensively summarized by Hanahan and Weinberg (2000) in their review on the essential alterations in cell physiology that establish malignant growth.

Tumors are characterized by six essential alterations in cell physiology: self-sufficiency in growth signals, insensitivity to growth-inhibition signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis [ 2, 3].

The pathway of tumor formation is a multistep journey including at least six essential alterations in cell physiology that collectively dictate malignant growth and the spread of transformed cell clones [ 79].

Is the essential alteration in them, in the environment or in both?

Many of the essential alterations occurring in cell physiology during carcinogenesis are mediated via extracellular cell signalling pathways that interact with intracellular circuits.

They are six essential alterations of cell physiology that generally occur in cancer cells independently of the originating tissue type.

It has been suggested that only a few essential functional alterations in the physiology of the cells, the so-called hallmarks of cancer, are behind the vast catalog of cancer genotypes [ 11].

Fumigation of P. cyclopium with C. citratus essential oil, induced alterations in both the lipid content and the fatty acids methyl esters composition of the cells (Helal et al. 2006).