Sentence examples for essential alteration in from inspiring English sources

Is the essential alteration in them, in the environment or in both?

As even minor temperature shifts strongly influence the growth and development in salmonids and cause essential alterations in life history patterns, any long-term non-adaptive variation in response to thermal conditions is likely to have important consequence on individual physiology and fitness [49].

Neoplastic overgrowth involves essential alterations in cell physiology, loss of cell proliferation control and resistance to cell death.

These essential alterations in cell physiology are, amongst others, achieved by the constitutive activation of oncogenes and the loss of tumor suppressor gene (TSG) function.

In general, the contributions of MAPK, CREB, and PTEN to the cell circuitry involved in carcinogenesis are also comprehensively summarized by Hanahan and Weinberg (2000) in their review on the essential alterations in cell physiology that establish malignant growth.

Tumors are characterized by six essential alterations in cell physiology: self-sufficiency in growth signals, insensitivity to growth-inhibition signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis [ 2, 3].

The pathway of tumor formation is a multistep journey including at least six essential alterations in cell physiology that collectively dictate malignant growth and the spread of transformed cell clones [ 79].

This may be particularly true in carcinogenesis, where, "six essential alterations in cell physiology collectively dictate malignant growth: self-sufficiency in growth signals, insensitivity to growth-inhibitory (antigrowth) signals, evasion of programmed cell death (apoptosis), limitless replicative potential, sustained angiogenesis and tissue invasion and metastasis" (Hanahan & Weinberg, 2000).

These genes were selected for their role in six essential alterations in cell physiology that collectively dictate malignant growth (Gilles et al, 1996; Bellet et al, 1997; Hendrix et al, 1997; Vlodavsky et al, 1999; Butler et al, 2000; Hanahan and Weinberg, 2000).

In 2000, Hanahan et al. (21) gave structure to this rapidly growing field of research with the proposal that 'the vast catalog of cancer cell genotypes [could be organized into] a manifestation of six essential alterations in cell physiology that collectively dictate malignant growth'.

Hanahan and Weinberg describe how virtually all mammalian cells carry a similar molecular machinery regulating their proliferation, differentiation, and death and suggest that there are six essential alterations in cell physiology that collectively dictate malignant growth (Hanahan and Weinberg 2000) and this framework can be applied to GC, as described previously (Milne et al. 2007).