Sentence examples for essential activator of from inspiring English sources

We next inhibited TORC1 activity selectively in PTEN clones by co-overexpression of Tuberous Sclerosis Complex-1 and -2 (Tsc1/2)—which together form a complex with GTPase activating protein (GAP) activity towards the small GTPase Rheb, an essential activator of TORC1 (Garami et al., 2003; Zhang et al., 2003)—or by removing Rheb function.

Cdc25 functions as an essential activator of Cdks by dephosphorylating Cdks at inhibitory sites [ 7]; p53 activates transcription of p21 which then inhibits Cdk activation [ 1].

This AR activity was not detectable with the ATN6 polypeptide, and thus, for this activity, the ATC3 polypeptide may be considered to be an essential activator of the ATN6 polypeptide.

These results indicate that ATP is an essential activator of KpBest.

As such, cholesterol is now considered an essential activator of ABCG2 function, probably acting as a slowly transported substrate, an allosteric co-activator or a co-transporter28.

The master circadian clock, located in the suprachiasmatic nucleus (SCN), is an essential activator of downstream molecular events critical to the generation of circadian rhythms (Dunlap, 1999).

The need for essential activators of the helicase activity represents a change in the model about the mode of action of eukaryotic replicative helicases and could help to explain the delay between the assembly of the MCM2 7 complexes on the chromatin during late telophase/early G1 and the initiation of DNA replication several hours later (Mendez & Stillman, 2000).

We also present a framework for degraders as programmable essential activators of ubiquitin ligase enzymes, connecting their features as catalysts with established enzymology concepts.

Toll-like receptors (TLR) are essential activators of the innate part of the vertebrate immune system.

SWR1 recruitment to nucleosome-deficient or nucleosome-free regions (NFRs) of yeast promoters is due to its preference for nucleosomes adjoining long linker DNA (Ranjan et al., 2013), but post-recruitment activation of the SWR1 complex requires binding of both its natural substrates the canonical nucleosome and the H2A.Z-H2B dimer—which also serve as essential activators of SWR1 (Luk et al., 2010).

The data presented demonstrate that saposin C is a non-essential enhancer for GC degradation in vivo at the levels produced in these mice in vivo, i.e. GCase residual activity is present, whereas with an essential activator, a total deficiency of GCase function would exist.